Publications

2025

  • scellop: A Scalable Redesign of Cell Population Plots for Single-Cell Data
    Thomas C Smits, Nikolay Akhmetov, Tiffany S Liaw, Mark S Keller, Eric Moerth, Nils Gehlenborg
    arXiv
    _scellop_: A Scalable Redesign of Cell Population Plots for Single-Cell Data
  • HuBMAP Data Portal: A Resource for Multi-Modal Spatial and Single-Cell Data of Healthy Human Tissues
    Morgan L Turner, Thomas C Smits, Tiffany S Liaw, Brendan Honick, Bill Shirey, Lisa Choy, Nikolay Akhmetov, Shaokun An, David Betancur, Dominic Bordelon, Karl Burke, Ivan Cao-Berg, John Conroy, Chris Csonka, Penny Cuda, Sean Donahue, Stephen Fisher, Derek Furst, Ed Hanna, Josef Hardi, Tabassum Kakar, Mark S Keller, Xiang Li, Yan Ma, Allison McWilliams, Austen Money, Richard Morgan, Eric Moerth, Juan Muerto, Mark A Musen, Emily Nic, Martin J O'Connor, Gesina Phillips, Alex Ropelewski, Ryan Sablosky, Sravani Saripalli, Max Sibilla, Derek Simmel, Alan Simmons, Xu Tang, Joel Welling, Zhou Yuan, Martin Hemberg, Matt Ruffalo, Jonathan Silverstein, Philip Blood, Nils Gehlenborg
    arXiv
    HuBMAP Data Portal: A Resource for Multi-Modal Spatial and Single-Cell Data of Healthy Human Tissues
  • GQVis: A Dataset of Genomics Data Questions and Visualizations for Generative AI
    Skylar Sargent Walters, Arthea Valderrama, Thomas C Smits, David Kouřil, Huyen N Nguyen, Sehi L'Yi, Devin Lange, Nils Gehlenborg
    IEEE 2025 1st Workshop on GenAI, Agents, and the Future of VIS (VIS x GenAI)
    GQVis: A Dataset of Genomics Data Questions and Visualizations for Generative AI
  • Ten Simple Rules for Making Biomedical Data Resources Accessible
    Thomas C Smits, Lawrence Weru, Sehi L'Yi, Nils Gehlenborg
    PLoS Computational Biology, 21(11): e1013657
    Ten Simple Rules for Making Biomedical Data Resources Accessible
  • A comprehensive evaluation of life sciences data resources reveals significant accessibility barriers
    Sehi L’Yi, Harrison G Zhang, Andrew P Mar, Thomas C Smits, Lawrence Weru, Sofía Rojas, Alexander Lex, Nils Gehlenborg
    Scientific Reports, 15, 23676
    A comprehensive evaluation of life sciences data resources reveals significant accessibility barriers
  • Multimodal Retrieval of Genomics Data Visualizations
    Huyen N Nguyen, Sehi L'Yi, Thomas C Smits, Shanghua Gao, Marinka Zitnik, Nils Gehlenborg
    OSF Preprints
    Multimodal Retrieval of Genomics Data Visualizations
  • The State of Single-Cell Atlas Data Visualization in the Biological Literature
    Mark S Keller, Eric Moerth, Thomas C Smits, Simon Warchol, Qianwen Wang, Robert Krueger, Hanspeter Pfister, Nils Gehlenborg
    IEEE computer graphics and applications, 45(5), 18-34
    The State of Single-Cell Atlas Data Visualization in the Biological Literature

2024

  • AltGosling: Automatic Generation of Text Descriptions for Accessible Genomics Data Visualization
    Thomas C Smits, Sehi L’Yi, Andrew P Mar, Nils Gehlenborg
    Bioinformatics, 40(12), btae670
    Award Runner-Up Abstract Award at ISMB BioVis 2025
    AltGosling: Automatic Generation of Text Descriptions for Accessible Genomics Data Visualization
  • Explaining Unfamiliar Genomics Data Visualizations to a Blind Individual through Transitions
    Thomas C Smits, Sehi L’Yi, Huyen N Nguyen, Andrew P Mar, Nils Gehlenborg
    IEEE 2024 1st Workshop on Accessible Data Visualization (AccessViz)
    Explaining Unfamiliar Genomics Data Visualizations to a Blind Individual through Transitions
  • Using OpenKeyNav to Enhance the Keyboard-Accessibility of Web-based Data Visualization Tools
    Lawrence Weru, Sehi L’Yi, Thomas C Smits, Nils Gehlenborg
    OSF Preprints
    Using OpenKeyNav to Enhance the Keyboard-Accessibility of Web-based Data Visualization Tools

2023

  • Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)
    Sanjay Jain, Liming Pei, Jeffrey M Spraggins, Michael Angelo, James P. Carson, Nils Gehlenborg, Fiona Ginty, Joana P. Gonçalves, James S. Hagood, John W. Hickey, Neil L. Kelleher, Louise C. Laurent, Shin Lin, Yiing Lin, Huiping Liu, Alexandra Naba, Ernesto S. Nakayasu, Wei-Jun Qian, Andrea Radtke, Paul Robson, Brent R. Stockwell, Raf Van de Plas, Ioannis S. Vlachos, Mowei Zhou, HuBMAP Consortium, Katy Börner, Michael P. Snyder
    Nature Cell Biology 25, 1089–1100 (2023)
    Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)
  • Digital Accessibility of Life Science Data Portals and Journal Websites
    Sehi L’Yi, Thomas C Smits, Alexander Lex, Nils Gehlenborg
    OSF Preprints

2022

  • Somatic Changes Prior to the Development of Hyperdiploidy Expose Mutation Accumulation Rate and Activated Processes in Multiple Myeloma
    Thomas C Smits, Anil Aktas Samur, Romain Lannes, Mariateresa Fulciniti, Masood Shammas, Jill Corre, Kenneth Anderson, Giovanni Parmigiani, Hervé Avet-Loiseau, Nikhil Munshi, Mehmet Samur
    Blood, 140(Supplement 1), 168837
    Award American Society of Hematology Abstract Achievement Award
    Somatic Changes Prior to the Development of Hyperdiploidy Expose Mutation Accumulation Rate and Activated Processes in Multiple Myeloma
  • PHF19 Inhibits Multiple Myeloma Cell Response to Immunotherapy Via Promoting Immunosuppressive Microenvironment
    Tengteng Yu, Mu Hao, Hailin Chen, Kenneth Wen, Tingjian Wang, Thomas Smits, Mehmet Samur, Eugenio Morelli, Lijie Xing, Liang Lin, Jun Qi, Gang An, Nikhil Munshi, Yu-Tzu Tai, Lugui Qiu, Kenneth Anderson
    Blood, 140(Supplement 1), 159137
    Award American Society of Hematology Abstract Achievement Award
  • OAB-017: Mutations accumulated before and after hyperdiploidy reveal timing and impact of chromosomal gains on multiple myeloma
    Thomas C Smits, Anil Aktas Samur, Romain Lannes, Mariateresa Fulciniti, Masood Shammas, Jill Corre, Kenneth Anderson, Giovanni Parmigiani, Hervé Avet-Loiseau, Nikhil Munshi, Mehmet Samur
    Clinical Lymphoma, Myeloma and Leukemia, Volume 22, S10 - S11
    Award International Myeloma Society Young Investigator Award
    OAB-017: Mutations accumulated before and after hyperdiploidy reveal timing and impact of chromosomal gains on multiple myeloma
  • OAB-031: PHF19 promotes multiple myeloma cell resistant to daratumumab/isatuximab via upregulation in immunosuppressive microenvironment and reduced CD38 target expression
    Tengteng Yu, Hailin Chen, Kenneth Wen, Tingjian Wang, Phillip Hsieh, Thomas C Smits, Mehmet Samur, Lijie Xing, Liang Lin, Mu Hao, Lugui Qiu, Yu-Tzu Tai, Kenneth Anderson
    Clinical Lymphoma, Myeloma and Leukemia, Volume 22, S18 - S19
  • OAB-013: Universal loss of BCL7A allows release of its binding partner IRF4 inducing its transcriptional activity promoting MM cell growth
    Chandraditya Chakraborty, Srikanth Talluri, Eugenio Morelli, Sanika Derebail, Yan Xu, Charles Epstein, Thomas Smits, Moritz Binder, Kenneth Anderson, Masood Shammas, Mehmet Samur, Mariateresa Fulciniti, Nikhil Munshi
    Clinical Lymphoma, Myeloma and Leukemia, Volume 22, S8

Additional

  • Accessibility in Grammar-Based Genomics Visualization Language Gosling through Automatic Generation of Text Descriptions
    Thomas C Smits, Sehi L’Yi, Nils Gehlenborg
    HMS Master’s Programs Research Symposium
  • Workspaces in Portal: Data Linking and Templates in Jupyter Lab
    Thomas C Smits, Nikolay Akhmetov, Lisa Choy, John Conroy, Mark Keller, Tiffany Liaw, Juan Puerto, Samson Toor, Morgan L Turner, Philip Blood, Nils Gehlenborg
    HuBMAP Demo Day
  • Workspaces in Portal (in progress): templates allow for easy cell type composition exploration
    Thomas C Smits, HuBMAP Harvard HIVE-TC, HiDIVE Lab
    HuBMAP Annual Meeting